Urolithins are ellagic acid metabolites and derivatives of ellagic acid components like ellagitannins. The gut bacteria convert ellagic acidic derivatives into these chemical components.

So because intestinal flora is just so vital for urolithin synthesis, the amount of urolithins generated in the body is determined by the type of bacterial organisms in the flora, with Clostridium septum being the most significant. People with a microbiota rich in members of this group create much more urolithins than individuals with gut flora, including Bacteroides and Prevotella.

Urolithins- In Brief

Urolithins are a group of compounds that all belong to the urolithin family but differ in their chemical formulae, IUPAC designations, chemical structures, and sources. Furthermore, because these compounds have a wide range of applications and advantages on the body, they are promoted differently in supplement form.

Urolithins are formed in the stomach from punicalagin, just as ellagitannins, and subsequently expelled in the urine. To check potential urolithin formation in the body, assess the levels of ellagic acid in the urine of someone who has taken ellagic acid-rich meals or supplements containing urolithins as a key constituent. Urolithin may be found to consist of glucuronides once it has reached the plasma. 

Where are Urolithins found?

Urolithins can be found in various foods, albeit not all urolithin molecules can be obtained through food. Once ellagic acid-rich meals have been consumed, the gut flora must decompose ellagitannins or punicalagin into intermediary metabolites and finished goods, which are urolithin molecules.

Because of their anti-tumor, anti-aging, anti-inflammatory, and autophagy-inducing properties, these compounds had lately acquired popularity as superfood supplements. Furthermore, because urolithin molecules have a large influence on mitochondrial function, they increase energy levels. The mitochondria are responsible for energy generation inside the body, and one of Urolithins’ numerous tasks is to enhance the functionality of this organelle.

Urolithin A powder and Urolithin B powder, sometimes called UroA /UroB, are two well-called Urolithin metabolites found in the body. These are the same chemicals utilized in vitamins and nutritional supplement powders right now.

Urolithin A is identified as Urolithin A glucuronide in the blood, whereas Urolithin B is found as Urolithin B glucuronide. Because in vivo investigations on urolithins have not been feasible, it is assumed that they have the same properties as their ancestors. Due to a lack of in vivo investigations, it’s impossible to say if UroA / UroB glucuronides anyone has any impact other than UroA / UroB.

Urolithin A powder is another derivative of Urolithin A that may be identified in the blood. These derivatives carry out their roles in the bloodstream before being excreted through the urine. UrolithinD is yet another essential chemical generated by the intestinal microbiota; Urolithin A powder, when taken orally, was discovered to have an inhibitory impact on the inflammatory pathway and the apoptosis-inducing cascade, therefore preserving renal function.

Urolithins’ anti-inflammatory effects have been shown to combat chronic inflammation and repair organ damage caused by long-term inflammation, which has resulted in organ damage.